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Meanwhile, ROS is also involved in maintaining protein homeostasis, affecting ribosome biogenesis, mRNA translation, endoplasmic reticulum oxidative folding, and protein degradation through the ubiquitin-proteasomes and autophagy pathways

This creates what researchers describe as a feed-forward inflammatory loop, a cycle that sustains itself once initiated

It has been shown that rhein inhibits CYP2C9, CYP1A2, CYP2E1, CYP2D6 and CYP3A enzymes in rat liver (Tang et al., 2009)

Changes to the 2 position group can affect nucleic acid stability and affinity, 227 with common modifications including 2-fluoro (2-F), 2-O-methoxyethyl (2-MOE), and 2-O-methyl (2-OMe)